Maria Luz Fernandez, Ph.D
Professor
Ph.D. University of Arizona, 1988
Email: maria-luz.fernandez@uconn.edu
Education and Background
- B.S . Quimico Biologo University of Sonora (1970-1974) Hermosillo, Sonora Mexico.
- M.S. Food Science Instituto Politecnico Nacional (1975-1980) Mexico, D.F.
- Ph.D. Nutritional Sciences University of Arizona (1984-1988) Tucson, Arizona.
Professional Positions
- University of Connecticut, Storrs, CT, Department of Nutritional Sciences
- University of Arizona, Tucson Arizona, Department of Nutritional Sciences
- University of Sonora, Hermosillo, Sonora, Mexico, Department of Food Science
Professional Affiliations
- Joint Appointment(2000): Centro de Investigacion en Alimentos y Desarrollo (CIAD), Hermosillo, Mexico.
- Fellow, Council on Arteriosclerosis of the American Heart Association (elected 1992)
- Member, American Institute of Nutrition (elected 1992)
- Professional Member, Institute of Food Technologists (elected 1989)
Selected Awards and Honors
- 2001-Present - Associate Editor, The Journal of Nutrition
- Spring 2006 - Provost Research Award
- Fall 2005 - UCANRAA Teaching Award
- 2002 - Gamma Sigma Delta, Junior Faculty Award
- 2001 - Excellence in Research Award, College of Agriculture
- 1999-2001 - Editorial Board Member, The Journal of Nutrition
Teaching
- NUSC 165, The Basic Nutrition Course for non-majors
- NUSC 233/235 Class/Lab Food Composition and Methods of Preparation, a required course for Dietetics students.
- NUSC 315 Lipoproteins in Health and Disease, Spring semester every other year.
Graduated M.S. Students
- Lin He (1/95-12/96)
“Interactive effects of dietary carbohydrate type and fat saturation on hepatic cholesterol and lipoprotein metabolism in guinea pigs.
Oral exam Nov. 5, 1996
- Taif Al-Sarraj (8/95-8/97)
“Effects of exercise and hormone replacement therapy on reverse cholesterol transport in post-menopausal women”
Oral exam July 21, 1997.
- Hong Shen (8/95 - 12/97)
“Gender Differences in the responses to pectin, guar gum and psyllium on VLDL and LDL Metabolism”
Oral exam November 19, 1997.
- Ed Cos (1/99-8/00)
“Dietary soluble fiber and soybean protein reduce atherosclerotic lesions in guinea pigs. Gender and hormonal status determine lesion extension”
Oral Exam August 29, 2000.
- Jason Rosen (8/98-1/01).
"The effects of a comprehensive weight reduction intervention in obese post-menopausal women on plasma lipids and leptin metabolism”
Oral Exam January, 23. 2001.
- Madhu Patalay (8/02-12/04)
"The lowering of plasma lipids following a weight reduction program is related to increased expression of the LDL receptor and lipoprotein lipase"
Oral Exam November 12, 2004.
-
Lisa Zola (1/05-7/06)
"Project TLC (Therapeutic Lifestyle Changes)"
Oral Exam, July 19, 2006.
-
Ushma Vaishnav (8/05-12/07)
Seminar Title: Lutein’s dual role in the prevention of age-related macular degeneration and coronary heart disease risk.
-
Shymaa Ata (1/07-5/08)
Thesis Title: Obesity incidence among women from developing countries. The link between adiponectin and the metabolic syndrome.
Oral Exam, May 6, 2008.
-
Ryan DeOgburn (8/07-7/09)
Thesis Title: Increased Dietary Cholesterol in Conjunction with Carbohydrate Restriction Uniquely Impacts Hepatic Lipid Metabolism in a Guinea Pig Model.
Oral Exam June 30, 2009.
-
Daniela Ackermann 8/08-8/09
Thesis Title: Correlations between dietary intake and parameters of the metabolic syndrome in women.
Oral Exam July 23, 2009.
Graduated Ph.D. Students
- Karin Conde (1/95 - 5/98)
“HMG-CoA reductase inhibitors: atorvastatin and simvastatin. Hypocholesterolemic mechanisms of action in the guinea pig”.
Oral Exam March 27, 1998.
Current Position: Senior Scientist, Hoffman-La Roche, Nutley, NJ
- Marcela Vergara-Jimenez (8/94 - 5/98)
“Mechanisms by which pectin and psyllium reverse the hyperlipidemia induced by high fat and high sucrose diets in guinea pigs”
Oral Exam April 15, 1998.
Current Position. Assistant Professor, University of Sinaloa in Mexico.
- Suheeta Roy (1/98-5/01):
“Gender and hormonal status modulate the hypolipidemic mechanisms of dietary soluble fiber in the guinea pig”.
Oral Exam April 23, 2001.
Current Position: Post-doctoral Fellow,
- Tripurasundari Ramjiganesh (8/98-9/01)
“Regulation of hepatic cholesterol and lipoprotein metabolism by corn fiber oil and sitostanol in guinea pigs”
Oral Exam, September 14, 2001.
Current Position: Post-doctoral Fellow, Brigham and Women’s Hospital, Harvard Medical School
- Sonia Vega-Lopez (8/98-5/02)
“Gender and hormonal status modulate the effects of psyllium on the mechanisms determining plasma lipids and lipoprotein metabolism”
Oral Exam, April 30, 2002.
Current Position. Post-doctoral position in Tufts University, Boston, MA
- Kristy West (8/00-5/04)
"The mechanisms by which SC-435, an ileal, apical sodium co-dependent bile acid transporter inhibitor (ASBT) alters LDL cholesterol concentrations and hepatic cholesterol metabolism in guinea pigs"
Oral Exam, March 26, 2004.
Current Position: Medical Writer, Custom Learning Designs, Inc, Belmont, MA
- Kristin Herron (8/00-5/04)
“The individual response to a diet high in cholesterol provided by eggs. Does response affect coronary heart disease risk?”
Oral Exam April 9, 2004
Current Position: Senior Scientist, Nutrition Research, Kraft Foods
- Ingrid Lofgren (8/01-8/04)
"Effects of a weight loss program including calorie restriction, exercise and a dietary supplement on lipoprotein metabolism"
Oral Exam, July 28, 2004
Current Position: Faculty Member, Dept of Nutrition and Animal Science, University of New Hampshire, Durham NH
- Tosca Zern (8/01-5/05)
“Cardioprotective effects of grape polyphenols in the postmenopausal state”
Oral Exam March 22, 2005
Current position: Research Associate, Yale University
- Martha Nydia Ballesteros (8/01-12/05) (from joint appointment with CIAD, Hermosillo, Mexico).
“Evaluation of the metabolic response to dietary cholesterol in school-aged children”.
Oral Exam November 30, 2005
Current position: Senior Scientist: Centro de Investigación en Desarrollo y Alimentos.
- Dimple Aggarwal (6/03-5/06)
“Guinea pigs as models for experimental drugs affecting triglyceride metabolism”
Oral exam February 27, 2006
Current Position: Post-Doctoral Fellow, Schering, Plough, NJ
- Richard Wood (8/03-5/06)
“Effects of a low carbohydrate diet with and without soluble fiber supplement on coronary heart disease risk and lipoprotein metabolism”
Oral Exam March 17, 2006
Current Position: Post-Doctoral Fellow, Medical School, Pittsburgh, PA
- Christine Greene (8/03-5/06)
“Response to dietary cholesterol and carotenoids provided by eggs in an elderly population”
Oral Exam April 28, 2006
Current Position: Lecturer, Department of Nutritional Sciences, University of Connecticut
- Sudeep Shrestha (1/04-5/07)
“The effects of a combination therapy with psyllium and plant sterols on clinical markers of cardiovascular disease and lipoprotein metabolism.”
Oral Exam January 8, 2007
Current position: Post-doctoral fellow, Harvard School of Medicine, Boston, MA
- Moises Torres-Gonzalez (8/04-6/07)
“Carbohydrate restriction and dietary cholesterol distinctly affect hepatic cholesterol and lipoprotein metabolism in guinea pigs.”
Oral Exam June 14, 2007
Current position: Post-doctoral Fellow, Linus Pauling Institute, Corvallis, OR
- Gisella Mutungi (4/06-12/07)
“Potential of eggs in enhancing the cardioprotective effects of carbohydrate restricted diets in weight loss interventions.”
Oral Exam December 6, 2007
Current position: Post-doctoral fellow Southwestern Medical Center, Dallas, TX
- Michael Puglisi (8/05-5/08)
“Raisin effects on biomarkers of coronary heart disease in men and women aged 50-70 years.”
Oral Exam, April 24, 2008
Current Position: Post-doctoral fellow, Vanderbilt University, Nashville, TN
- Taif Al-Sarraj (1/06-5/09)
“Effect of carbohydrate restriction and American Heart Association diets on the clinical features of the metabolic syndrome, the inflammatory response and lipoprotein metabolism in young Emirati Adults”
Oral Exam, January 30, 2009
Current Position: Department Head in Nutrition, Tawam Hospital, Al-Ain Abudabhi, UAE.
- Joseph Ratliff
“Modulation of inflammatory response and appetite regulation by egg intake.”
Oral Exam, May 1, 2009
Current Position: Post-doctoral fellow, Yale University
- Jose O Leite
“Modulation of atherosclerosis and lipid metabolism by drug treatment and dietary interventions.”
Oral Exam, June 16, 2009
Current Position: Cardiovascular Fellow, Barcelona, Spain
Current Students
M.S.
- Michael Comperatore (8/08)
- Brandon LaPia (8/09)
Ph.D.
- Mariana Calle (1/07)
“Assessment of inflammation in diabetes, a peer counseling intervention and in chronic and acute exercise”
- Jennifer Rogers (8/07)
“Effects of a soy, plant sterol-based supplement on factors associated with the metabolic syndrome in adult women.”
- Shymaa Ata (8/08)
“Dietary lutein effects on lipid metabolism and eye health.”
- Jacqueline Barona (8/08)
“Effects of grape polyphenols on the metabolic syndrome”
- Jung Eun Kang (8/08)
“Dietary lutein effects on atherosclerosis in guinea pigs”
- Tina Checchio (5/09)
- Christopher Blesso (8/09)
- Christine Dugan (8/09)
- Lynn Turner (8/09)
Post-Doctoral Fellows
- Ghada Abdel Fattah, Ph.D. (September - December 1995).
- Reyna Luz Vidal-Quintanar, Ph.D. (July-December 1999)
Visiting Professor
- Jung Sook Kang (December 2004-2005)
Department of Food and Nutrition, -Cheju National University, Korea
- Hyeon Sook Lim (June-August 2008)
Department of Nutrition – Chonnam National University
Research
My research focuses on studying the mechanisms by which lifestyle factors and gender/hormonal status affect cholesterol and lipoprotein metabolism and their relationship to heart disease. Clinical studies conducted in my laboratory include: children, men, pre-menopausal and post-menopausal women to determine how gender and hormonal status influence the cholesterolemic response to dietary factors and lifestyle changes. Lifestyle factors include dietary factors (dietary soluble fiber, dietary cholesterol, low fat diets, fatty acids varying in the degree of saturation and chain length, complex and simple carbohydrates), obesity and exercise. I use the guinea pig as my animal model to study specific effects of dietary factors, drugs and gender on hepatic enzymes, secretion and turnover of lipoproteins and lipoprotein changes in the intravascular compartment plus atherosclerosis and inflammatory cytokines. Molecular approaches are also used by measuring mRNA abundance of target genes involved in hepatic cholesterol homeostasis and in synthesis and catabolism of lipoproteins.
Grants and Funding History
Sponsor |
Project Title |
Amount |
Year |
Egg Nutrition Board. |
Hamsters and guinea pig studies on the responses to dietary cholesterol utilizing animals with different levels of HDL |
$31,601.00 |
1/97-12/97 |
Parke-Davis |
Mechanisms of plasma cholesterol and triacylglycerol lowering by atorvastatin |
$19,300.00 |
1/97- 12/97 |
School of Public Health, Loma Linda University |
Visceral Fat and Risk of Cardiovascular Disease |
$2,500.00 |
9/97-6/98 |
Monsanto Company |
Mechanisms of plasma LDL cholesterol lowering by corn oil and sitostanol |
$ 47,181.00 |
4/98 - 5/99. |
USDA |
Gender Effects on the Hypolipidemic Mechanisms of Dietary Fiber |
$155,000.00 |
7/98-6/01 |
Egg Nutrition Board |
Gender and dietary components interact to determine plasma cholesterol levels and atherosclerotic lesions |
$34,948.00. |
9/98-8/99. |
Egg Nutrition Board |
Beneficial Effects of Eggs on Plasma Lipoprotein Metabolism. Differences between Caucasian and Latino women |
$46,123.00 |
7/00-6/01 |
Pharmacia |
Mechanisms of plasma cholesterol lowering by an ileal sodium dependent bile acid transporter (ASBT) inhibitor |
$104,519.00 |
11/00-5/02 |
The California Table Grape Commission |
Favorable effects of grapes on LDL oxidation and atherosclerotic lesions. Studies in ovariectomized guinea pigs, a model for Menopause |
$25,000.00 |
6/01-5/02 |
American Egg Board. |
Eggs as part of a Healthy Diet in Mexican Children |
$49,689.00 |
1/02-12/02 |
University of Sonora |
Plantago ovata and cholesterol metabolism in guinea pigs |
$4,600.00 |
6/01-12/01 |
Loma Linda University. |
Effects of a nut-based diet on plasma lipids and lipoproteins |
$15,000.00 |
1/02-12/02 |
American Egg Board |
Post-doctoral fellowship, Kristin Herron |
$55,000.00 |
7/02-6/04 |
Lonza Inc. |
Effects of L-carnitine on body composition and plasma lipids |
$310,000.00 |
8/02-12/04 |
The California Table Grape Commission |
Cardioprotective Effects of Grape Polyphenols in Pre- and Post-menopausal Women |
$25,000.00 |
7/03-6/04 |
Akros, Pharmacological Co |
Effects of MPT inhibitor in lipoprotein metabolism in guinea pigs |
$80,000.00 |
1/04-5/05 |
American Egg Board |
Response to dietary cholesterol provided by eggs in an older population |
$64,274.00 |
7/04-6/05 |
NIH/Subcontract |
Molecular signaling of rapamycin induced hypertriglyceridemia. |
$8.600.00 |
1/05-8/05 |
Integrative Health and Research Inc. |
A soluble fiber and plant sterol-containing cookie for lowering cholesterol: A randomized, double blind, placebo-controlled study. |
$63,000.00 |
5/05-4/06 |
The California Raisin Marketing Board |
Raisin effects on biomarkers of coronary heart disease in elderly men and women |
$74,565.00 |
4/06-3/07 |
Egg Nutrition Center |
Potential of eggs in enhancing the cardiprotective effects of carbohydrate restricted diets in weight loss interventions |
$112,862.00 |
7/06-12/07 |
Anthera Pharmaceuticals |
Evaluation of a drug that inhibits Phospholipase-2 |
$39,237.00 |
6/07-1/08 |
Egg Nutrition Center |
Eggs: Potential for dual protection. Age related macular degeneration and cardiovascular disease |
$67,184.00 |
5/08-5/09 |
Metagenics, Inc |
Effects of a soy, plant sterol containing supplement on cardiovascular disease risk factors in subjects with the metsyn |
$245,028.00 |
8/08-12/09 |
USDA |
Fellowships; “Diet and Obesity” |
$258,000.00 |
9/08-8/13 |
Recent Presentations
- March 17, 2003 – Centro de Investigacion y Desarrollo, Hermosillo, Mexico “Effects of weight loss on body composition and lipoprotein metabolism”
- May 1, 2003 – Congreso de ANECA, Veracruz, Mexico “The Multiple Contributions of Eggs to a Healthy Diet”
- August 9, 2003 – Hoffman-LaRoche Nutley, NJ “Drug therapy and animal models for cholesterol and lipoprotein metabolism”
- November 10, 2003 – SLAN, Acapulco Mexico “Egg Consumption and Nutritional and Health Advantages”
- April 1 & 2, 2004 – El Instituto del Huevo, Mexico City, Mexico “The misinformation regarding the relationship between egg consumption and cardiovascular disease” “Egg Consumption in school children. Metabolic Response”
- August 18, 2004 – Laboratorio Estatal de Saluld Publica, Hermosillo, Mexico “Saturated fat, dietary cholesterol and risk for cardiovascular disease”
- October 13, 2004 – Universidad de Sinaloa, Mexico “The Metabolic Síndrome”
- April 15 2005 – Department of Animal Science and Nutrition, University of New Hampshire HMG-CoA reductase inhibitors. Mechanisms of action and multiple effects on heart disease risk.
- October 5 2005 – University of Panama, Panama City, Panama “Diet effects on the metabolic syndrome”
- October 6, 2005 – Instituto del Huevo Latinomericano, Panama City, Panama “ Eggs, an incredible source of nutrients”
- November 1, 2005 – Wyeth Pharmaceuticals “Guinea pigs as models for diet and drug effects on lipoprotein metabolism”
- January 22, 2006 – Invited Speaker: Nutrition and Metabolism Society, Brooklym NY “Carbohydrate restriction reduces atherosclerosis and alters the distribution of lipoprotein subfractions in guinea pigs”
- March 6, 2006 – Invited Speaker: Wayne University, Detroit, MI “New Findings regarding dietary cholesterol and lipoprotein metabolism”
- September 26-29, 2006 – Invited Speaker: 4 Radio Interviews, 3 TV Interviews and 1 conference to 550 Health professionals in Buenos Aires, Argentina on the nutritional benefits of eggs
- November 16, 2006 – Invited Speaker: The Metabolic Syndrome, Instituto de la Nutricion, Mexico City, Mexico
- December 13, 2006 – Invited Speaker: Broad Institute: Guinea pig genome Project meeting.
- February 16,2007 – Invited Speaker: Egg Institute, Armenia, Colombia. Benefits of Eggs across the age spectrum.
- March 6, 2007 – Invited Speaker: Metabolex Inc., San Mateo, California Drug therapy and guinea pigs as models for cholesterol and lipoprotein metabolism.
- May 17, 2007 – Invited Speaker: Diet and Optimal Health, Portland, OR November 1, 2007 Invited Speaker, Nutrition Society of Korea, Seoul, Korea January 13, 2008 Invited Speaker, Tawam Hospital, United Arab Emirates
- March 3, 2008 – Invited Speaker: Department of Allied Health, University of Connecticut April 8, 2008 Experimental Biology, San Diego California
- April 16, 2008 – Manielli Lecture, University of Rhode Island, Kingston, RI April 30, 2008 Invited Speaker, Clinical Chemistry Society, Universidad de Antioquia, Medellin, Colombia
- May 2, 2008 – Key Speaker, National Microbiology Society, Medellin, Colombia May 30, 2008 Invited Speaker, Presentation of Functional Foods Initiative in the Graduate School to Officers from Germany.
- October 16, 2008 – Invited Speaker; University of Sinaloa, Mexico. October 31, 2008 Invited Speaker, Department of Animal Science, University of Connecticut “Egg effects on lipoprotein metabolism and inflammation”
- November 21, 2008 – Invited Speaker, Graduate School. Presentation of the Graduate Program to Minority faculty from other Institutions.
- February 13, 2009 – Key Note Speaker, University of Sonora, Hermosillo Sonora
Publications
Refereed Journal Articles
- Al-Sarraj T, Saadi H, Volek JS, Fernandez ML. Metabolic syndrome prevalence, dietary intake and cardiovascular risk profile among overweight and obese adults from the United Arab Emirates. Met Syndr Rel Disord. 2009 (in press)
- Al-Sarraj T, Saadi H, Volek JS, Fernandez ML. Carbohydrate restriction favorably alters lipoprotein metabolism in Emirati subjects classified with the metabolic syndrome. Nutr. Met Cardiovasc. Dis. 2009 (in press)
- Al-Sarraj T, Saadi H, Calle MC, Volek JS, Fernandez ML. Carbohydrate restriction as a first-line dietary intervention therapy effectively reduces the biomarkers of metabolic syndrome in Emirati adults. J. Nutrition. 2009 (in press)
- Ata SM, Vaishnav U, Puglisi M, Wood RJ, Lofgren IE, Volek JS, Fernandez ML. Macronutrient composition and increased physical activity modulate plasma adipokines and appetite hormones during a weight loss intervention. J. Women Health. 2009 (in press).
- Carr TP, Staneck Krostrand KL, Schelgel VL, Fernandez ML. Stearate-enriched plant sterol esters lower serum LDL cholesterol concentration in normo- and hypercholesterolemic adults. J. Nutr. 2009 (in press).
- Fernandez ML, Torres-Gonzalez M. Carbohydrate restriction prevents atherosclerosis by reducing atherogenic lipoproteins and aortic inflammatory cytokines in guinea pigs. 2009 www.athero.org/commentaries.
- Leite JO, DeOgburn R, Ratiliff J, Su R, Volek JS, McGrane MM, Dardik A, Fernandez ML. Low carbohydrate diets disrupt the association between insulin resistance and weight gain. Metabolism 2009: (in press)
- Ratliff J, Puglisi M, Mutungi G, Volek JS, Fernandez ML. Carbohydrate restriction (with or without additional dietary cholesterol provided by eggs) reduces insulin resistance and plasma leptin without modifying appetite hormones in adult men. Nutr. Res. 2009:29:262-268.
- Leite JO, Vaishnav U, Puglisi M, Fraser H, Trias J, Fernandez ML. A-002 (Varesplabid), a phospholipase A2 inhibitor reduces aterosclerosis in guinea pigs. BMC Cardiovascular Disorders. 2009; 9:7.
- Fernandez ML. The LDL to HDL cholesterol ratio, a more reliable clinical tool than LDL cholesterol to evaluate coronary heart disease risk. The Lipid Spin, 2009; 4:4-6.
- Shrestha S, Ehlers SJ, Lee J-Y, Fernandez ML, Koo SI. Dietary green tea extract lowers plasma and hepatic triglycerides by decreasing the expression of SERBP-1 mRNA and its responsive genes in fructose-fed ovariectomized rats. J. Nutr. 2009; 139:640-645.
- Wood RJ, Fernandez ML. Carbohydrate Restriction versus Low Glycemic Index Diets: which is a better option for the treatment of insulin resistance and the metabolic syndrome? Nutr. Rev. 2009;67:179-183.
- Mutungi G, Waters D, Ratliff J, Puglisi MJ, Clark RM, Volek JS, Fernandez ML. Eggs distinctly modulate plasma carotenoid and lipoprotein subclasses in adult men following a carbohydrate restricted diet. J Nutr Biochem. 2009; (Epub ahead of print).
- Volek JS, Phinney SD, Forsythe CE, Quann EE, Wood RJ, Puglisi MJ, Kraemer WJ, Bibus DM, Fernandez ML, Feinman RD. Carbohydrate restriction has a more favorable impact on the metabolic syndrome than a low fat diet. Lipids. 2009; 44:297-309.
- Puglisi M, Mutungi G, Brun PJ, McGrane MM, Volek JS, Fernandez ML. Raisins and walking alter appetite hormones and plasma lipids by modifications in lipoprotein metabolism and up-regulation of the LDL Receptor. Metabolism 2009; 58:120-128.
- Visloky LM, Pikosky MA, Herron KL, Vega-Lopez S, Gaine PC, Martin WW, Zern TL, Fernandez ML, Rodriguez NR. Habitual consumption of eggs does not alter the beneficial effects of endurance training on plasma lipids and lipoprotein metabolism in untrained men and women. J. Nutr. Biochem 2009;20:26-34.
- Fernandez ML. Marcadores de Inflamación en Enfermedades Cardiovasculares. Medicina y Laboratorio. 2008, 14:1-7
- Puglisi M, Fernandez ML. Modulation of C reactive protein, tumor necrosis-alpha and adiponectin by diet, exercise and weight loss. J Nutr 2008; 138:2293-2296.
- Torres-Gonzalez M, Volek JS, Leite JO, Fraser H, Fernandez ML. Carbohydrate restriction reduces lipids and inflammation and prevents atherosclerosis in guinea pigs. J. Arterioscler. Thromb 2008; 15:235-243.
- Puglisi M, Vaishnav U, Shrestha S, Torres-Gonzalez M, Wood RJ, Volek JS, Fernandez ML. Raisins and additional walking have distinct effects on plasma lipids and inflammatory cytokines. Lipids Health Dis. 2008; 7:14.
- Volek JS, Fernandez ML, Feinman RD, Phinney SD. Dietary carbohydrate restriction induces a unique metabolic state positively affecting atherogenic dyslipidemia, fatty acid partitioning and metabolic syndrome. Progress in Lipid Res. 2008; 47:307-318.
- Seip R, Volek JS, Windemuth A, Kocherla M, Fernandez ML, Kraemer WJ, Ruano G. Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat. Nutr Metab (Lond) 2008: 5:4
- Ratliff J, Mutungi G, Puglisi M, Volek JS, Fernandez ML. Eggs modulate the inflammatory response to carbohydrate restricted diets in overweight men. Nutr. Metab (Lond). 2008: 5:6.
- Mutungi G, Ratliff J, Puglisi M, Torres-Gonzalez M, Vaishnav U, Leite JO, Quann E, Volek JS, Fernandez ML. Dietary cholesterol from eggs increases HDL cholesterol in overweight men consuming a carbohydrate restricted diet. J. Nutr. 2008;138:272-276.
- Pasiakos Stephan M, Metel JB, West KL, Lofgren IE, Fernandez ML, Koo SI, Rodriguez NR. Effects of a weight loss intervention on resting energy expenditure and substrate oxidation in premenopausal women. Metabolism 2008; 57:458-464
- Sharman MJ, Fernandez ML, Zern TL, Allen SS, McMurray DN & Volek JS. Increased aortic inflammation in the guinea pig with dietary-induced atherosclerosis. J, Nutr. Biochem 2008;19:732-738.
- Forsythe C, Phinney S, Fernandez ML, Quann EE, Wood RJ, Bibus DM, Kraemer WJ, Feinman RD, Volek JS. Comparison of low fat and low carbohydrate diets on circulating fatty acid composition and markers of inflammation. Lipids 2008;43:65-67.
- Torres-Gonzalez M, Leite JO, Volek JS, Contois JH, Fernandez ML. Carbohydrate restriction and dietary cholesterol distinctly affect plasma lipids and lipoprotein subfractions in adult guinea pigs. J. Nutr. Biochem. 2008;19:856-863.
- Fernandez ML & Webb D. The LDL to HDL cholesterol ratio as a valuable tool to evaluate coronary heart disease risk. The impact of dietary cholesterol. J. Am. Coll. Nutr. 2008; 27:1-5.
- Mutungi G, Torres-Gonzalez M, McGrane MM, Volek JS, Fernandez ML. Carbohydrate restriction and dietary cholesterol modulate the expression of HMG-CoA reductase and the LDL receptor in mononuclear cells from adult men. Lipids Health Dis 2007;28:34.
- Torres-Gonzalez M, Shrestha S, Freake HC, Volek JS, Fernandez ML. Carbohydrate restriction alters hepatic cholesterol metabolism in guinea pigs fed a hypercholesterolemic diet. J. Nutr. 2007;137:2219-2223.
- Leite JO & Fernandez ML. 2007. Commentary Atherosclerotic lesion formation in rabbits fed on egg yolk-supplemented diet: an inexpensive experimental model. J. Vasc. Bras. 2007; 6:197-198.
- Kang HW, Bimidi GR, Odon DP, Brun PJ, Fernandez ML & McGrane MM. Altered lipid catabolism in the Vitamin a deficient liver. Mol Cell Endocrinol. 2007; 271:18-27.
- Shrestha S, Freake HC, McGrane MM, Volek JS & Fernandez ML A combination of psyllium and plant sterols alters lipoprotein metabolism in hypercholesterolemic subjects by decreasing CETP activity and up-regulating LDL receptor in mononuclear cells. J. Nutr. 2007;137:1165-1170.
- Fernandez ML Acculturation and biomarkers for type 2 diabetes in Latinos. J. Nutr. 2007; 137:871-872.
- Waters D, Clark RM, Greene CM, Contois JH, Fernandez ML. Change in plasma lutein after egg consumption is positively associated with cholesterol and lipoprotein size but diminished with obesity in postmenopausal women. J. Nutr. 2007;137:973-978.
- Fernandez ML. The Metabolic Syndrome. Nutr. Rev. 2007; 64:S30-S34.
- Fernandez ML. Diet and Lipid Metabolism. Nutrition and the M.D. 2007;33:1-3.
- Greene CM & Fernandez ML. The role of nutrition in the prevention of cardiovascular disease in women of the developed world. Asian Pacific J. Clin. Nutr.2007;16:1-9.
- Wood RJ, Fernandez ML, Sharman MJ, Silvestre R, Greene CM, Zern TL, Shrestha S, Judelson DA, Gomez AL, Kramer W & Volek JS. Effects of a carbohydrate restricted diet with and without supplemental soluble fiber on plasma LDL-cholesterol and other clinical markers of cardiovascular risk Metabolism 2007;56:58-67.
- Aggarwal D, Soliman G, Freake HC, Dutta A, Fernandez ML. Validation of Using Gene Expression In Mononuclear Cells As A Marker For Hepatic Cholesterol Metabolism. Lipids Health Dis. 2006;5:22.
- Shrestha S, Volek JS, Udani J, Wood R, Greene C, Aggarwal D, Contois JH, Kavoussi B& Fernandez ML. A combination therapy including psyllium and plant sterol lowers LDL cholesterol by modifying lipoprotein metabolism in hypercholesterolemic individuals. J. Nutr. 2006;136:2492-2497.
- Wood RJ, Volek, Davis SR, Dell’Ova C, Fernandez ML. Carbohydrate restriction favorably affects plasma markers for cardiovascular disease. Nutr & Met 2006;3:19.
- Ruaño G, Windemuth A, Kocherla M, Holford T, Fernandez ML, Forsythe CE, Wood RJ, Kraemer WJ, Volek JS Physiogenomic analysis of weight loss induced by dietary carbohydrate restriction. Nutr & Met 2006;3:20
- Fernandez ML, Volek JS. Guinea pigs: A Suitable Animal Model to study Lipoprotein Metabolism, Atherosclerosis and Inflammation. Nutr. Metab. 2006;3:17.
- Herron KL, McGrane MM, Lofgren IE, Waters D, Clark RM, Ordovas JM & Fernandez ML. ABCG5 polymorphism contributes to the individual response to dietary cholesterol and to carotenoids present in eggs. J. Nutr. 2006;136: 1161-1165.
- Aggarwal D, Fernandez ML & Soliman GA. Rapamycin, an mTOR inhibitor disrupts triglyceride metabolism in guinea pigs. Met. Clin. Exp. 2006;55:794-802.
- Fernandez ML, Wood R & Volek JS. Carbohydrate restricted diets alter the size, distribution and concentration of lipoprotein subclases in men following a weight reduction program. 2006; http//www.athero.org/commentaries/
- Torres-Gonzalez M, Volek JS, Sharman M, Contois JH & Fernandez ML. Dietary carbohydrate and cholesterol influence the number of particles and distributions of lipoprotein subfractions in guinea pigs. J. Nutr. Biochem. 2006;17:773-779.
- Greene CM, Waters D, Clark RM, Contois JH & Fernandez ML. Plasma LDL and HDL characteristics and carotenoid content are positively influenced by egg consumption in an elderly population. Nutr. Met 2006;3:6
- Clark RM, Herron KL, Waters D & Fernandez ML. Hypo- and hyper-response to egg cholesterol predicts lutein and beta-carotene plasma concentrations in men and women. J. Nutr. 2006;136:601-607.
- Wood RJ, Volek JS, Liu Y, Shachter NS, Contois JH & Fernandez ML. Carbohydrate restriction alters lipoprotein metabolism by modifying VLDL, LDL and HDL subfraction distribution and size in overweight men. J. Nutr. 2006;136:384-389.
- Herron KL, Lofgren IE, Adiconis X, Ordovas JM & Fernandez ML. 2006. Associations between plasma lipid parameters and APOC3 and APOA4 genotypes in a healthy population are independent of dietary cholesterol intake. Atherosclerosis: Atherosclerosis 2006; 184:113-120.
- Aggarwal D, West KL, Zern TL, Shrestha S, Vergara-Jimenez M & Fernandez ML. JTT-130, a microsomal transfer protein inhibitor lowers plasma triglycerides and LDL cholesterol concentrations without increasing hepatic triglycerides in the guinea pig. BMC Card. Dis. 2005;5:30.
- Lofgren IE, Herron KL, West KL, Zern TL, Brownhill R, Ilich-Ernst J , Koo SI & Fernandez ML. A weight loss program favorably modifies anthropometrics and reverses the metabolic syndrome and insulin resistance in premenopausal women. Am J. Coll. Nutr. 2005;24:486-493.
- Fernandez ML. Dietary cholesterol provided by eggs and plasma lipoproteins in healthy populations. Curr. Op. Med Nutr. Met Care 2005;9:8-12.
- Greene CM, Zern TL, Wood R, Shrestha S, Aggarwal D, Sharman M, Volek JS & Fernandez ML. Maintenance of the LDL cholesterol: HDL cholesterol ratio in an elderly population given a dietary cholesterol challenge. J. Nutr. 2005;135: 2793-2798.
- Zern TL & Fernandez ML. 2005. Cardioprotective effects of dietary polyphenols J. Nutr. 2005;135:2291-2294
- West KL, McGrane MM, Odon D, Kelley BL & Fernandez ML. SC-435, an ileal apical sodium-codependent bile acid transporter (ASBT) inhibitor alters mRNA levels and enzyme activities of selected genes involved in hepatic cholesterol and lipoprotein metabolism in guinea pigs. J. Nutr. Biochem 2005;16:722-728.
- Fernandez ML & West KL. Mechanisms by which dietary fatty acids modulate plasma Lipids J. Nutr. 2005;135: 2075-2078.
- Zern TL, Wood R, Greene CM, West KL, Liu Y, Aggarwal D, Shachter NS, Fernandez ML. Grape polyphenols lower plasma lipids and apolipoproteins associated with increased risk for cardiovascular disease in pre and post-menopausal women. J. Nutr. 2005;135:1911-1947.
- Lofgren IE, Zern TL, Herron KL, West KL, Sharman M, Volek JS Shachter NS, Koo SI & Fernandez ML. Weight loss reduces the atherogenicity of LDL in premenopausal women. Metabolism Clin. Exp 2005;54:1133-1141.
- Fernandez ML & Vega-Lopez S. Efficacy and safety of β-sitosterol in the management of blood cholesterol levels. Cardiovasc. Res. 2005;23:73-86.
- Lofgren IE, Herron KL, West KL, Zern TL, Patalay M, Koo SI & Fernandez ML. Carbohydrate intake is correlated with biomarkers for coronary heart disease in a population of overweight premenopausal women. J. Nutr. Biochem. 2005;16:245-250.
- Patalay MK, Lofgren IE, Freake HC, Koo SI, Fernandez ML. The lowering of plasma lipids following a weight reduction program is related to increased expression of the LDL receptor and lipoprotein lipase. J. Nutr. 2005;135:735-739.
- Ballesteros MN, Cabrera RM, Saucedo MS, Aggarwal D, Shachter NS & Fernandez ML. Identification of risk factors for chronic disease in a population of children from Northern Mexico. J. Nutr. 2005;135:70-73.
- Fernandez ML, Metghalchi S, Vega-López S, Conde-Knape K, Lohman TG & Cordero-MacIntyre Z. Beneficial effects of weight loss on plasma apolipoproteins in postmenopausal women. J. Nutr. Biochem. 2004;15:717-721.
- Ballesteros MN, Cabrera RM, Saucedo MS & Fernandez ML. Dietary cholesterol does not increase biomarkers for chronic disease in a pediatric population at risk from Northern Mexico. Am. J. Clin. Nutr. 2004;80: 855-861.
- Lofgren IE, Herron KL, Zern TL, West KL, Patalay M, Shachter NS, Koo SI & Fernandez ML. Waist circumference is a better predictor than body mass index of coronary heart disease risk in overweight premenopausal women J. Nutr. 2004;134: 1071-1076.
- Cordero-MacIntyre Z, Metghalchi S, Rosen J, Warrens P, Lohman T & Fernandez ML. Impact of weight loss on plasma leptin in obese postmenopausal women treated with phenteremine hydrochloride. J. Applied Research 2004;4:60-67.
- West KL & Fernandez ML. Guinea pigs as models to study the hypocholesesterolemic effects of drugs. Cardiovascular Reviews. 2004;22:7-22.
- Herron KL, Lofgren IE, Sharma M, Volek JS & Fernandez ML. A high intake of dietary cholesterol does not result in more atherogenic LDL particles in men and women independent of response classification. Metab. Clin. Exp 2004;53:823-830.
- Herron KL & Fernandez ML. Are the current dietary guidelines regarding egg consumption appropriate? J. Nutr. 2003;134: 187-190.
- West KL, Zern TL, Butteinger D, Keller BT & Fernandez ML. SC-435, an ileal apical sodium co-dependent bile acid transporter (ASBT) inhibitor lowers plasma cholesterol and reduces atherosclerosis in guinea pigs. Atherosclerosis 2003;171:201-210.
- Zern TL, West KL & Fernandez ML. Grape polyphenols decrease plasma triglycerides and reduce cholesterol accumulation in the aorta of ovariectomized guinea pigs. J. Nutr. 2003;133: 2268-2272.
- Herron KL, Vega-Lopez S, Ramjiganesh T, Conde-Knape K, Shachter N, Fernandez ML. Men classified as hypo- or hyper-responders to dietary cholesterol feeding exhibit differences in lipoprotein metabolism. J. Nutr. 2003;133:1036-1042.
- Greaves KA, Going SB, Fernandez ML, Anderson SA, Milliken LA, Lohman TG, Bassford T & McNamara DJ. Cholesteryl ester transfer protein and lecithin: Cholesterol acyltransferase activities in hispanic and anglo postmenopausal women . Metab. Clin. Exp. 2002;52:282-289.
- Vega-Lopez S., Freake HC & Fernandez ML. Sex and hormonal status modulate the effects of psyllium on plasma lipids and monocyte gene expression. J. Nutr. 2002;133:67-70.
- West KL, Ramjiganesh T, Roy S, Keller BT & Fernandez ML. SC-435, an ileal, apical sodium-dependent bile acid transporter inhibitor (ASBT) alters hepatic cholesterol metabolism and lowers plasma low-density-lipoprotein-cholesterol concentrations in guinea pigs. J. Pharmacol Exp. Theraup. 2002;303: 291-299.
- Ensign W, McNamara DJ & Fernandez ML. Exercise improves plasma lipid profiles and modifies lipoprotein composition in guinea pigs. J. Nutr. Biochem. 2002;12: 747-753.
- Roy S, Freake HC & Fernandez ML. Gender and hormonal status affect the regulation of hepatic cholesterol 7a-hydroxylase activity and mRNA abundance by dietary soluble fiber in the guinea pig. Atherosclerosis. 2002;163:29-37.
- Herron KJ, Vega-Lopez S, Conde K, Ramjiganesh T, Roy S, Shachter N & Fernandez ML. Pre-menopausal women classified as hypo-or hyper-responders, do not alter their LDL/HDL ratio following a high dietary cholesterol challenge. J. Am. Coll. Nutr.2002; 21:250-258.
- Romero AL, West KL, Zern TL & Fernandez ML. The seeds from Plantago ovata lower plasma lipids by altering hepatic and bile acid metabolism in guinea pigs. J. Nutr. 2002;132: 1194-1198.
- Vega-Lopez S, Conde K, Vidal-Quintanar RL, Shachter NS & Fernandez ML. Sex and Hormonal Status Influence the Effects of Psyllium on Lipoprotein Remodeling and Composition. Metab. Clin Exp. 2002;51:500-507.
- Ramjiganesh T, Roy S, Freake HC, McIntyre J & Fernandez ML. Corn fiber oil lowers plasma cholesterol by altering hepatic cholesterol metabolism and by up-regulating hepatic LDL receptors in guinea pigs. J. Nutr. 2002; 131:335-340.
- Cos E, Ramjiganesh T, Roy S, Yoganathan S, Nicolosi RJ and Fernandez ML.Soluble fiber and soybean protein reduce atherosclerotic lesions in guinea pigs. Sex and hormonal status determine lesion extension. Lipids. 2001;11:1209-1216.
- Fernandez ML, West KL, Roy S & Ramjiganesh T. Dietary fat saturation and gender/hormonal status modulate plasma lipids and lipoprotein composition J. Nutr. Biochem 2001;12:703-710.
- Vega-Lopez S., Vidal-Quintanar RL and Fernandez ML. Sex and hormonal status modulate the plasma lipid responses to psyllium. 2001;Am J. Clin. Nutr. 74:435-441.
- Ramjiganesh T, Roy S, McIntyre J & Fernandez ML. The hypocholesterolemic effects of sitostanol are in part related to changes in hepatic lipids and lipoprotein composition in guinea pigs Brit. J. Nutr. 2001;85:165-172.
- Fernandez, ML. 2001. Guinea pigs as models for cholesterol and lipoprotein metabolism. J. Nutr. 131:10-20.
- Fernandez ML. Soluble fiber and non-digestible carbohydrate effects on plasma lipids and cardiovascular risk. Curr. Op. Lipidiol. 2001;12:35-40.
- Hasegawakatz T, Lohman T, Fernandez ML, & Cordero-MacIntyre Z. A prospective study on a weight reduction program and its impact on blood lipids, insulin and glucose levels, blood pressure and health practices. J. Fukui Med. Univ 2000;1: 383-400.
- Ramjiganesh T, Roy S, Young TL, Nicolosi R, McIntyre J & Fernandez ML. Corn husk oil lowers plasma LDL cholesterol concentrations by decreasing cholesterol absorption and altering hepatic cholesterol metabolism in guinea pigs J. Nutr. Biochem. 2000;11:358-366.
- Fernandez ML, Roy S & Vergara-Jimenez M. Resistant starch and cholestyramine have distinct effects on hepatic cholesterol metabolism in guinea pigs fed a hypercholesterolemic diet. Nutr. Res. 2000;20:837-850.
- Cordero-MacIntyre Z, Lohman TG, Rosen J, Peters W, España RC, Dickinson B, Reid PM, Howell WH and Fernandez ML. Weight loss is correlated with an improved lipoprotein profile in obese post-menopausal women. J. Am. Coll. Nutr. 2000;19:275-284.
- Roy S, Vega-Lopez S & Fernandez ML. Gender and hormonal status affect the hypolipidemic mechanisms of dietary soluble fiber in guinea pigs. J. Nutr. 2000;130:600-607.
- Conde K, Roy S, Freake HC, Newton R & Fernandez ML. Atorvastatin and simvastatin have distinct effects on hydroxy methylglutaryl-CoA reductase activity and mRNA abundance in the guinea pig. Lipids 1999;34:1327-1332.
- Conde K, Pineda G, Newton R & Fernandez ML. Hypocholesterolemic effects of 3-hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) reductase inhibitors in the guinea pig. Atorvastatin versus Simvastatin. Biochem. Pharmacol. 1999;58:1209-1219.
- Fernandez ML, Wilson TA, Conde K, Vergara-Jimenez M & Nicolosi RJ. Hamsters and guinea pigs differ in their plasma lipoprotein cholesterol distribution when fed diets varying in animal protein, soluble fiber or cholesterol content. J. Nutr. 1999;129:1323-1332.
- Vergara-Jimenez M, Furr HC & Fernandez ML. Pectin and psyllium decrease the susceptibility of LDL to oxidation in guinea pigs. J. Nutr. Biochem. 1999;10:118-124.
- Sun D-M, Fernandez ML, Lin ECK & McNamara DJ. Regulation of guinea pig hepatic acyl-CoA:cholesterol acyltransferase activity by dietary fat saturation and cholesterol. J. Nutr. Biochem. 1999;10:172-180.
- Vidal-Quintanar RL, Mendivil RL, Peña M and Fernandez ML. Lime-treated maize husks lower plasma LDL-cholesterol in normal and hypercholesterolemic adult men from northern Mexico. Brit. J. Nutr. 1999; 81:281-288.
- Romero AL, Romero JE, Galaviz S & Fernandez ML. Cookies enriched with psyllium and oat bran lower plasma LDL-cholesterol in normal and hypercholesterolemic men from Northern Mexico. J. Am. Coll. Nutr.1998;17: 601-608.
- Shen H, He L, Price RL & Fernandez ML. Dietary soluble fiber lowers plasma LDL cholesterol concentrations by altering lipoprotein metabolism in female guinea pigs. J. Nutr. 1998;128:1434-1441.
- Fernandez ML, Avalos C & Vergara-Jimenez M. Differences in response between 18 carbon fatty acids and 12/14 carbon saturated fatty acids on plasma cholesterol in guinea pigs. Nutr. Res. 1998;18:1261-1272.
- Montano C, Fernandez ML & McNamara DJ. Regulation of Apolipoprotein B-containing lipoproteins by Vitamin C level and dietary fat saturation in guinea pigs. Metab. Clin. Experim. 1998;47: 883-891.
- Vergara-Jimenez M, Conde K, Erickson S & Fernandez ML. Hypolipidemic mechanisms of pectin and psyllium in guinea pigs fed high fat-sucrose diets: alterations on hepatic cholesterol metabolism. J. Lipid Res. 1998;39:1455-1465.
- He L & Fernandez ML. Saturated fat and simple carbohydrates elevate plasma LDL cholesterol concentrations by specific alterations on hepatic cholesterol metabolism. Nutr. Res.1998;18:1003-1015.
- Abdel Fattah G, Fernandez ML & McNamara DJ. Regulation of very low density lipoprotein apo B metabolism by dietary fat saturation and chain length in the guinea pig. Lipids 1998;33:23-31.
- He L & Fernandez ML. Dietary carbohydrate type and fat saturation independently regulate hepatic cholesterol and LDL metabolism in guinea pigs J. Nutr. Biochem. 1998;9:37-46.
- Vidal-Quintanar RL, Hernandez L, Conde K. Vergara-Jimenez M & Fernandez ML. Lime-treated corn husks lower plasma LDL cholesterol in guinea pigs by altering hepatic cholesterol metabolism. J. Nutr. Biochem. 1997;8:479-486.
- Fernandez ML, Vega S, Ayala MT, Shen H, Conde K, Vergara-Jimenez M, & Robbins A. Vitamin C level and dietary fat saturation alter hepatic cholesterol homeostasis and plasma LDL metabolism in guinea pigs. J. Nutr. Biochem. 1997;8:414-424.
- Fernandez ML, Conde K, Vergara-Jimenez M, Behr T. & Abdel-Fattah G. Regulation of apolipoprotein B-containing lipoproteins by dietary soluble fiber in guinea pigs. Am. J. Clin. Nutr 1997;65:814-822.
- Conde K, Vergara-Jimenez M, Crouse B, Newton R & Fernandez ML. Hypocholesterolemic actons of atorvastatin are associated with alterations on hepatic cholesterol metabolism and lipoprotein composition in the guinea pig. J. Lipid Res. 1996;37:2372-2382.
- Fernandez ML, Vergara-Jimenez M, Conde K & Abdel-Fattah G. Dietary carbohydrate type and fat amount alter VLDL and LDL metabolism in guinea pigs. J. Nutr. 1996;126:2494-2504.
- Fernandez ML, McDonald BE, Soscia AE, Sun G-S & McNamara DJ. Olive oil and rapeseed oil differ in their effect on plasma low-density lipoprotein metabolism in the guinea-pig. Brit. J. Nutr 1996;76:869-880.
- Romero AL & Fernandez ML. Dietary fat amount and carbohydrate type regulate hepatic acyl CoA:cholesterol acyltransferase (ACAT) activity. Possible links between hepatic ACAT activity and plasma cholesterol levels. Nutr. Res.1996;16:937-948.
- Fernandez ML. Distinct mechanisms of plasma LDL lowering by dietary soluble fiber in the guinea pig. Specific effects of pectin, guar gum and psyllium. J. Lipid Res.1995;36: 2394-2404.
- Fernandez ML, Vergara M, Romero AL, Erickson S & McNamara DJ. Gender differences in response to dietary soluble fiber in guinea pigs: effects of pectin, guar gum and psylliium. J. Lipid Res.1995; 36: 2191-2202.
- Fernandez ML, Conde K, Ruiz L, Montano C & McNamara DJ. Carbohydrate type and amount alter intravascular processing and catabolism of plasma lipoproteins in guinea pigs. Lipids 1995;30:619-626.
- Fernandez ML, Sun DM, Montano CM & McNamara DJ. Carbohydrate-fat exchange and regulation of hepatic cholesterol homeostasis and lipoprotein metabolism Metabolism 1995;44:855-864.
- Abdel Fattah G, Fernandez ML & McNamara DJ. Regulation of guinea pig very low density lipoprotein secretion rates by dietary fat saturation. J. Lipid Res. 1995;36:1188-1198.
- Fernandez ML, Ruiz LR, Conde AK, Sun D-M, Erickson S & McNamara DJ. Psyllium reduces plasma LDL in guinea pigs by altering hepatic cholesterol metabolism. J Lipid Res 1995;36:1128-1138.
- Fernandez ML, Abdel Fattah G & McNamara DJ. Differential effects of simple and complex carbohydrates on VLDL secretion rates and HDL metabolism in the guinea pig. Biochim. Biophys. Acta 1995; 1256:31-38.
- Fernandez ML, Sun DM, Tosca M & McNamara DJ. Differential effects of guar gum on LDL and hepatic cholesterol metabolism in guinea pigs fed low and high cholesterol diets. A dose response study. Am. J. Clin. Nutr. 1995;61:127-134.
- Lin ECK, Fernandez ML, Tosca M & McNamara DJ. Dietary fat and cholesterol regulation of HDL metabolism: hepatic HDL binding and in vivo apolipoprotein A-I catabolism in guinea pigs. Atherosclerosis 1995;112:161-175.
- Fernandez ML, Lin ECK & McNamara, DJ. Dietary saturated fat composition modifies high density lipoprotein binding to guinea pig hepatic membranes. Nutr. Res. 1994;14:753-764.
- Fernandez ML, Lin ECK, Trejo A & McNamara DJ. Prickly pear (Opuntia sp) pectin alters hepatic cholesterol homeostasis without affecting cholesterol absorption in guinea pigs fed a hypercholesterolemic diet. J. Nutr. 1994;124:817-824.
- Fernandez ML, Sun D-M, Tosca M & McNamara DJ. Citrus pectin and cholesterol interact to regulate hepatic cholesterol homeostasis and lipoprotein metabolism. A dose response study in the guinea pig. Am. J. Clin. Nutr. 1994;59:869-878.
- Lin ECK, Fernandez, ML &McNamara DJ. Regulation of hepatic LDL metabolism in the guinea pig by dietary fat and cholesterol. J. Lipid Res. 1994;35: 446-457.
- Fernandez ML & McNamara DJ. Dietary fat saturation and chain length modulate guinea pig hepatic cholesterol metabolism. J. Nutr. 1994;124:331-339.
- Fernandez ML, Abdel-Fattah G & McNamara DJ. Dietary fat saturation modifies the metabolism of LDL subfractions in guinea pigs. Arterioscler. Thromb. 1993;14:1418-1428.
- Fernandez ML, Lin ECK, Trejo A & McNamara D.J. Prickly pear (Opuntia sp) reverses low density lipoprotein (LDL) receptor suppression induced by a hypercholesterolemic diet in guinea pigs. J. Nutr. 1992;122:2330-2340.
- Fernandez ML, Lin ECK & McNamara DJ. Differential effects of saturated fatty acids on low density lipoprotein metabolism in the guinea pig. J. Lipid Res.1992; 33:1833-1842.
- Lin ECK, Fernandez ML & McNamara DJ. Dietary fat type and cholesterol quantity interact to affect cholesterol metabolism in guinea pigs. J. Nutr.1992;122:2019-2029.
- Fernandez ML, Lin ECK & McNamara DJ. Regulation of guinea pig plasma low density lipoprotein kinetics by dietary fat saturation. J. Lipid Res. 1992;33:97-109.
- Fernandez ML & McNamara DJ.Regulation of cholesterol and lipoprotein metabolism in guinea pigs mediated by dietary fat quality and quantity. J.Nutr.1992;121:934-943.
- Fernandez ML & McNamara DJ. Characterization of high density lipoprotein binding to guinea pig hepatic membranes: Effects of dietary fat quality and cholesterol. Metabolism 1991;40:127-134.
- Fernandez ML,Trejo A, & McNamara DJ. Pectin isolated from prickly pear (Opuntia sp) modifies low density lipoprotein (LDL) in cholesterol-fed guinea pigs. J. Nutr. 1990;120:1283-1290.
- Fernandez ML, Yount NY & McNamara DJ. Whole body cholesterol synthesis in the guinea pig. Effects of dietary fat quality. Biochim. Biophys. Acta. 1990;1044:340-348.
- Fernandez ML & McNamara DJ. High density lipoprotein binding to guinea pig hepatic membranes. Comparison of guinea pig and human ligands. Biochim. Biophys. Acta. 1990;1042:142-145.
- Fernandez ML & McNamara DJ. Dietary fat mediated changes in hepatic apo B/E receptors in the guinea pig. Metabolism. 1989;38:1094-1102.
- Fernandez ML & Berry JW. Effect of germination on chickpea starch. Starch/Starke. 1988;41:17-21.
- Fernandez ML & Berry JW. Rheological properties of flour and sensory characteristics of bread made from germinated chickpea. Int. J. Food Sci Tech. 1988; 24:103-110
- Fernandez ML & Berry JW. Nutritional evaluation of chickpea and germinated chickpea flours. Plants Hum. Nutr. 1988;38:127-134.
- Fernandez de Tonella ML & Berry JW. Characteristics of a chocolate beverage from germinated chickpeas. J. Food Sci. 1987;52:726-728.
- Fernandez de Tonella ML & Yepiz MS Effects of lysine and methionine fortification on dough and bread characteristics. J. Food Sci. 1986;51:637-644.
- Fernandez de Tonella ML, Sanchez M and Salazar MG. Physical, chemical, nutritional and sensory properties of corn-based fortified food products. J. Food Sci. 1983;48:1637-1643.
- Fernandez de Tonella ML, Taylor RR & Stull JW. Properties of a chocolate based chickpea beverage. Cereal Foods World 1981;26
Book Chapters
- Fernandez ML. Fiber, Cholesterol Reduction and Cardiovascular Disease in Edible Fiber Components: Nutritional and Health Benefits. Taylor and Francis Publishers, 2009 (in press)
- Fernandez ML & McNamara DJ. The Effects of eggs on plasma lipoproteins in healthy populations in “Eggs and Health” 2009;(in press).
- Fernandez ML & Wood RJ. Guinea pigs as models for human cholesterol and lipoprotein metabolism in Source book for models for Biomedical Research , Humana Press 2008 p. 201-212.
- Fernandez ML & Vergara-Jimenez M. 2005. "Associations between Carbohydrate Intake and Risk for Coronary Heart Disease, Insulin Resistance and the Metabolic Syndrome. In Focus on Dietary Carbohydrate Research. Nova Science Publishers, Inc. Hauppauge, NY.
- Fernandez ML. 1998. "Dietary Fiber and LDL Metabolism." European Symposium on functional properties of non-digestible carbohydrates. Lisbon Portugal. p 29-34.
- Fernandez ML. 1998. "Pectin: Composition, physico-chemical properties, food applications and physiological effects", in Handbook of Dietary fiber, 2nd edition. Marcel Dekker. New York, NY.
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News and Updates
Spring 2010 Seminar Series
A Seminar Series Presented by the Department of Nutritional Sciences at the University of Connecticut
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Positions Open
Professor & Director of Functional Foods Initiative
Nutritional Sciences, 75% Research and 25% Teaching, 10 month, tenure-track. – Applications and supporting materials will be reviewed beginning November 30, 2009 until the positions are filled.
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