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Alison B. Kohan, Ph.D.

Assistant Professor

Office: 211-D Advanced Technology Laboratory
Phone: 860-486-0866
Email: alison.kohan@uconn.edu
Website: kohanlab.com

Education

  • Ph.D. 2009 Biochemistry, West Virginia University
  • M.A. 2003 Science Education, West Virginia University
  • B.S. 2000 Molecular and Cellular Biology, University of Arizona

Professional Experience

  • Assistant Professor (2014 – Present), Department of Nutritional Sciences, University of Connecticut
  • Research Assistant Professor (2013 – 2014), Department of Pathology and Laboratory Medicine, University of Cincinnati
  • Adjunct Faculty (2011, 2012), Department of Zoology, Miami University
  • Postdoctoral Fellow (2009 – 2013), Department of Pathology and Laboratory Medicine, University of Cincinnati

Research Interests

The overall goal of my research is to determine the mechanisms through which intestinal apolipoproteins impact disease in human populations, and the therapeutic implications of this physiology. Major efforts in my research laboratory are focused on: (i) mechanism of apoC-III regulation of intestinal regulatory T cells (Tregs); (ii) the interplay between dietary lipid absorption and inflammatory bowel disease; and (iii) the influence of plasma lipoproteins, particularly triglyceride-rich lipoproteins with apoC-III, on intestinal lipid metabolism. My laboratory has extensive experience in intestinal lipid absorption, lipoprotein synthesis and secretion, plasma lipoprotein metabolism, and we developed the primary intestinal organoid model for the study of lipoprotein synthesis and secretion.

Sample Publications

  1. Li D, Dong H, Kohan AB. The Isolation, Culture, and Propagation of Murine Intestinal Enteroids for the Study of Dietary Lipid Metabolism. Methods Mol Biol. 2017 Sep 20. doi: 10.1007/7651_2017_69. [Epub ahead of print]
  2. Gaia Botteri, Marta Montori, Anna Gumà, Javier Pizarro, Lídia Cedó, Joan Carles Escolà-Gil, Diana Li, Emma Barroso, Xavier Palomer, Alison B. Kohan, Manuel Vázquez-Carrera. VLDL and apolipoprotein CIII induce ER stress and inflammation and attenuate insulin signaling via toll-like receptor 2 and ERK1/2 in skeletal muscle cells. Diabetelogia.Nov;60(11):2262-2273, 2017.
  3. Gabrielle West, Cayla Rodia, Diana Li, Zania Johnson, Hongli Dong, Kohan AB. Key differences between apoC-III regulation and expression in intestine and liver. Biochem Biophys Res Commun. Sep 23;491(3):747-753, 2017.
  4. Jattan J, Rodia C, Li D, Diakhate A, Dong H, Bataille A, Shroyer NF, Kohan AB. Using primary murine intestinal enteroids to study dietary TAG absorption, lipoprotein synthesis, and the role of apoC-III in the intestine. J Lipid Res. May;58(5):853-865, 2017.
  5. Kohan AB, Yang Q, Xu M, Lee D, Tso P. Monosodium glutamate inhibits the lymphatic transport of lipids in the rat. Am. J. Physiol. Gastrointest. Liver Physiol. 311 (4): G648-G654, 2016.
  6. Kohan AB. Apolipoprotein C-III: a potent modulator of hypertriglyceridemia and cardiovascular disease. Curr. Opin. Endocrinol. Diabetes. Obes. 22: 119–25, 2015.

Book Chapters and Reviews

  1. Kohan AB, Howles PN, Tso P. (2012) Methods in studying rodent intestinal lipoprotein production and metabolism. Current Protocols in Mouse Biology. Sep 1;2:219-230.
  2. Kohan AB, Yoder SM, Tso P. (2011) Using the lymphatics to study nutrient absorption and the secretion of gastrointestinal hormones. 2011. Physiology and Behavior. Nov 30;105(1):82-8.
  3. Kohan AB, Yoder S, Tso P. (2010) Lymphatics in intestinal transport of nutrients and gastrointestinal hormones. Annals of the New York Academy of Sciences. Oct;1207 Suppl 1:E44-51.

Grants

2014–2019—NIDDK Mentored Research Scientist Development Award (K01): “A unique role for apoC-III in intestinal lipoprotein synthesis and secretion.”

2011–2014—NIDDK Ruth L. Kirschstein National Research Service Award (F32): “The Regulation Of Hepatic Lipid Metabolism By Apo A-IV.”

2008–2009—NHLBI Pre-Doctoral Training Grant (T32): “Mechanism by Which Dietary Polyunsaturated Fat Regulates Lipogenic Gene Expression.”

News and Updates

Spring 2018 Seminar Series
A Seminar Series Presented by the Department of Nutritional Sciences at the University of Connecticut
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Scholarships

Please go to the CAHNR Scholarships and Financial Aid page for Scholarship information