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Bradley Bolling, PhD

Assistant Professor

Phone: (860)-486-2180
Email: bradley.bolling@uconn.edu

Education and Training

  • Postdoctoral Fellow, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Antioxidants Research Laboratory, in the Training in Education and Critical Research Skills (TEACRS Program, an NIH Institutional Research and Career Development Award (IRACDA) Training Grant. 2007-2010.
  • Ph.D., University of Wisconsin-Madison, Food Science, Food Chemistry Major, Distributed Minor with emphasis on aging and cancer. 2007.
  • Graduate certificate, University of Wisconsin-Madison Delta Program, Certificate in teaching and learning. 2007.
  • B.S., University of Wisconsin-Madison, Food Science, Honors in Research. 2002.

Professional Experience

  • Postdoctoral Fellow, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Antioxidants Research Laboratory. 2007-2010.
  • Adjunct Faculty, University of Massachusetts, Boston. Fall, 2009.
  • Graduate Research Assistant, Department of Food Science, University of Wisconsin-Madison.  2002-2007.
  • Teaching Assistant, Department of Food Science, University of Wisconsin-Madison. 2004-2005.
  • Undergraduate Research Assistant, Department of Food Science, University of Wisconsin-Madison. 2000-2002.

Honors and Awards

  • Hamish Munro Postdoctoral Excellence Award, HNRCA at Tufts University. 2009.
  • American Society for Nutrition (ASN) Dietary Bioactives Postdoctoral Poster Competition, 1st Place, Experimental Biology, New Orleans. 2009.
  • Institute of Food Technologists Student Association (IFTSA) Product Development Competition, 1st Place, IFT Annual Meeting. 2005.
  • Grand Prize Winner, Almond Innovations Contest. 2005.
  • American Oil Chemists Society Health and Nutrition Division Student Excellence Award. 2005
  • American Oil Chemists Society Honored Student Award. 2005.
  • American Oil Chemists Society Natural Health Research Institute Scholarship for Nutrition and Cancer Prevention or Treatment. 2004-2005.
  • Food Chemistry Division Paper Competition, 2nd Place, IFT Annual Meeting. 2003.
  • Donald A. Withycombe Fellowship, American Chemical Society, Food Chemistry Division. 2003.
  • Institute of Food Technologists (IFT) Graduate Fellowship. 2003.
  • Hilldale Undergraduate Research Fellowship. 2002.
  • Wisconsin Academic Achievement Scholarship.1998-2002.

Professional Affiliations

  • American Society for Nutrition, 2007-present.
  • American Chemical Society, 2002-present.
  • American Oil Chemists Society, 2002-2009.
  • Institute of Food Technologists, 2001-present.

Research Interests

Chronic diseases account for 70% of all deaths in the United States. Lifestyle and diet have the potential to reduce the risk and complications of chronic disease. Increasing polyphenol intake is a promising intervention to reduce chronic disease burden. For example, it is estimated that lifestyle and diet changes can reduce chronic disease risk by 80%. However, incomplete knowledge regarding abundance, metabolism, and bioactivity has limited the ability to recommend polyphenols and other dietary bioactives for disease prevention. I have been working to answer the following questions to fill these knowledge gaps:

What is the polyphenol content of food supply?
What bioactive agents are most promising for disease prevention?
Does polyphenol metabolism change with age?

Answering the unknown questions about the ability of polyphenols or other bioactives to prevent chronic disease will help substantiate dietary advice. Diet intervention can be safe, low-cost, and implemented over a broad population. It may also be more attractive to consumers than drugs. Confronting these problems now is timely because of the rapidly expanding elderly population, and the high cost of chronic disease to healthy living and health care. Our approach is organized to translate fundamental nutrition research to practical implementation. It is flexible enough to be adapted to different bioactive agents, research questions, and health outcomes.

Publications

Peer-reviewed Research

  • Bolling, B., Ji, L., Parkin, K. Dietary supplementation of ferulic acid and ferulic acid ethyl ester induces quinone reductase and glutathione-S-transferase in rats. Food Chemistry (2011),124(1), 1-6.
  • Bolling, B., Blumberg, J., Chen, C-Y. Oliver. The influence of roasting, pasteurization, and storage on the polyphenol content and antioxidant capacity of California almond skins. Food Chemistry (2010), 123(4), 1040-1047.
  • Bolling, B., Dolnikowski, G., Blumberg, J., Chen, C-Y. Oliver. Polyphenol content and antioxidant activity of California almonds depend on cultivar and harvest year. Food Chemistry (2010), 122(3), 819-825.
  • Andarwulan, N., Batari, R. Sandrasari, D. A., Bolling, B., Wijaya, H. Flavonoid content and antioxidant activity of vegetables from Indonesia.  Food Chemistry (2010), 121(4), 1231-1235.
  • Bolling, B., Court, M. H., Blumberg, J., Chen, C-Y. Oliver. The kinetic basis for age-associated changes in quercetin and genistein glucuronidation by rat liver microsomes, Journal of Nutritional Biochemistry (2010), 21(6), 498-503.  
  • Bolling, B., Dolnikowski, G., Blumberg, J., Chen, C-Y. Oliver. Quantification of almond skin polyphenols by liquid chromatography-mass spectrometry. Journal of Food Science (2009), 74(4), C326-C332.
  • Bolling, B., Blumberg, J., Chen, C-Y. Oliver. Extraction methods determine the antioxidant capacity and induction of quinone reductase by soy products in vitro. Food Chemistry. (2009), 116(1), 351-355.
  • Bolling, B., Parkin, K. Limited contribution of isoflavones to hepatocellular phase II enzyme-inducing activity of soybean (Glycine max) extracts. Food Chemistry (2009), 113, 1069-1075.
  • Bolling, B., Parkin, K. Phenolic derivatives from soy flour ethanol extract are potent in vitro quinone reductase (QR) inducing agents. Journal of Agricultural and Food Chemistry (2008), 56, 10473-10480.
  • Bolling, B., Chen, E., Parkin, K.  Quinone reductase inducing and antioxidant activities of aqueous isolates of green bean (Phaseolus vulgaris L.).  Food Research International (2007), 40(1), 182-190.
  • Lee, C-H, Wettasinghe, M, Bolling, B., Ji, L., Parkin, K.  Betalains, phase II enzyme-inducing components from red beetroot (Beta vulgaris L.) extracts. Nutrition and Cancer (2005), 53(1), 91-103.
  • Wettasinghe, M., Bolling, B., Plhak, L., Xiao, H., Parkin, K.  Phase II enzyme-inducing and antioxidant activities of beetroot (Beta vulgaris L.) extracts from phenotypes of different pigmentation. Journal of Agricultural and Food Chemistry (2002), 50(23), 6704-6709.
  • Wettasinghe, M., Bolling, B., Plhak, L., Parkin, K.  Screening for phase II enzyme-inducing and antioxidant activities of common vegetables. Journal of Food Science (2002), 67(7), 2583-2588.
  • Ingham, S.C., Bolling, B., Schmidt, D.J.  Development of a simple method for detecting presumptive Escherichia coli on fresh retail beef. Journal of Food Science (2002), 67(1) 258-261.

Reviews

  • Bolling, B., McKay, D, Blumberg, J. The phytochemical composition and antioxidant actions of tree nuts. Asia Pac J Clin Nutr.(2010), 19(1), 117-123.
  • Bolling, B., Chen, C-Y., Blumberg, J.  Tea and health: Preventive and therapeutic usefulness in the elderly? Current Opinion in Clinical Nutrition and Metabolic Care (2009), 12, 42-48

Presentations

Oral

  • Bolling, B. Backwards course design & gaining IRB approval for educational research: lessons from Food Fights 101. 2010 IRACDA Conference. Boston, MA.
  • Bolling, B. Flavonoids and health: Where are we? Jean Mayer USDA HNRCA at Tufts University. Hamish Munro Postdoctoral Excellence Award Seminar. May, 2009.
  • Bolling, B.  Metabolism of plant flavonoids- changes in older individuals. Half-day Seminar on Natural Antioxidants: Chemistry, Biochemistry and Technology. Invited seminar speaker. Bogor, Indonesia, Sept 16, 2008.
  • Bolling, B.,   Blumberg, J. B., Chen, C.-Y. O.Contribution of polyphenols to the total antioxidant capacity of pomegranate and grape juices. FASEB J (2010). 24, 321.2. Experimental Biology, Anaheim, CA, April 24-28, 2010.
  • Bolling, B., Dolnikowski, G., Blumberg, J., Chen, C-Y. Harvest year and growing region but not processing affect flavonoid content and antioxidant capacity of California almond skins. FASEB J (2009). 23, 337.4. Experimental Biology, New Orleans, LA, April 12-22, 2009.
  • Bolling, B. Age-related changes of flavonoid glucuronidation in F344 Male Rats. Tufts HNRCA Seminar Series. Tufts University, Boston MA. Oct 20, 2008.
  • Bolling, B., Court, M., Blumberg, J., Chen, C-Y. Age-associated changes in flavonoid glucuronidation by male F344 rat liver microsomes. Volunteered oral technical paper. 12th International Glucuronidation and UGT Workshop. Quebec, Canada, July 24-27, 2008.
  • Bolling, B., Parkin, K. Bioactivity-guided isolation of in vitro quinone reductase (QR) inducing agents from soybean (Glycine max ssp.). Volunteered oral technical paper, 233rd ACS National Meeting, Chicago, IL, United States, March 25-28, 2007.
  • Bolling, B., Parkin, K. Active components in an in vitro quinone reductase-inducing ethanolic fraction from soybean (Glycine max ssp.). Volunteered oral technical paper, IFT Annual Meeting, New Orleans, LA, United States, July 15-20, 2005.
  • Bolling, B., Parkin, K. Isolation and identification of in vitro quinone reductase-inducing components from soybean (Glycine max ssp.). Volunteered oral technical paper. AOCS 96th Annual Meeting, Salt Lake City, UT, United States, May 1-4, 2005.
  • Parkin, K., Wettasinghe, M., Bolling, B., Xiao, H., Peterson, D. Methodological considerations for the murine hepatoma cell bioassay-directed isolation of cancer chemopreventive agents. 223rd ACS National Meeting, Orlando, FL, United States, April 7-11, 2002.

Poster

  • Bolling, B., Blumberg, J., Chen, C.-Y. O. Total antioxidant capacity of grape and pomegranate juices in vitro is dependent upon assay dilution factor. FASEB J. (2010) 24, 921.2. Experimental Biology, Anaheim, CA. April 24-28, 2010.
  • Bolling, B., Court, M., Blumberg, J., Chen, C-Y. Age-related changes in hepatic and intestinal quercetin glucuronidation in rats. Volunteered technical paper. 4th International Conference on Polyphenols and Health, Yorkshire, England, December 7-11, 2009.
  • Bolling, B., Blumberg, J., Chen, C-Y. The influence of roasting, pasteurization, and storage conditions on polyphenol content and antioxidant capacity of California almond skins. Volunteered technical paper. 4th International Conference on Polyphenols and Health, Yorkshire, England, December 7-11, 2009.
  • Bolling, B., Court, M., Blumberg, J., Chen, C-Y. Age-related increases in F344 rat intestine microsomal quercetin glucuronidation. Volunteered technical paper. NIH IRACDA Conference, San Francisco, CA, June 7-9, 2009.
  • Bolling, B., Court, M., Blumberg, J., Chen, C-Y. Age-related increases in F344 rat intestine microsomal quercetin glucuronidation. FASEB J (2009). 23, 750.1. Experimental Biology, New Orleans, LA, April 12-22, 2009.
  • Bolling, B., Court, M., Blumberg, J., Chen, C-Y. Age-associated changes in flavonoid glucuronidation by male F344 rat liver microsomes. Poster Presentation. NIH IRACDA Conference, Chapel Hill, NC, June 8-11, 2008.
  • Bolling, B., Parkin, K., Chen, E.  Characterization of green bean isolates exhibiting antioxidant and phase II enzyme-inducing activities. Sci-Mix Poster Presentation, 226th ACS National Meeting, New York, NY, United States, September 7-11, 2003.
  • Bolling, B., Parkin, K., Chen, E.  Characterization of green bean isolates exhibiting antioxidant and phase II enzyme-inducing activities. IFT Annual Meeting, Chicago, IL, United States, June 12-16, 2003.
News and Updates

Fall 2011 Seminar Series
A Seminar Series Presented by the Department of Nutritional Sciences at the University of Connecticut
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Scholarships

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Positions Open

FHI Assistant Research Professor
Nutritional Sciences, 11month, non-tenure track—Screening will begin April 15, 2011 and continue until the position is filled.